Blood Physiology


What you will learn

Physiology of Blood


This course is about the physiology of blood. This course is organized into different sections to provide a detailed inside into various components of blood.

The first section is an introduction to blood and discusses the various components that blood is made up of.

The second section is about the fluid part of the blood which is known as plasma. Various components of the plasma are discussed in seperate lectures. A connection has been drawn between disease states that might arise due to a change in the composition of plasma.

The third section is about the various parameters of red blood cells. A connection has been drawn between the normal RBC structure and how it helps the RBC carry out its activities. Metabolic reactions, membrane proteins and synthesis of red blood cells are also discussed in this section.

The fourth section is about hemoglobin and many physiological aspects of hemoglobin are highlighted in this section along with the synthesis, breakdown and different types of hemoglobin.

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The fifth section is about Red blood indices that are commonly seen on blood reports. Please note that blood report interpretation in this course is only and only for educational purposes and is in no way a substitute to proper medical diagnosis.

The sixth,seventh,eighth and ninth sections of this tutorial are about various types of White blood cells. Many aspects related to basic immunology are highlighted in this section.

Finally the last section focuses on platelets and coagulation factors.




Introduction and components of Blood


Introduction to Plasma and Plasma proteins
Plasma electrolytes
Nutrients and waste products
Plasma vs Serum

Red blood cells

basics of red blood cells
Circular and biconcave structure
Central pallor
Red blood cell membrane proteins
Red blood cell – metabolic pathways
red blood cell production
Red blood cell amounts – How many Red blood cells do we have?


Introduction to Hemoglobin
Hemoglobin and oxygen transport
oxygen hemoglobin dissociation curve
Hemoglobin and carbondioxide transport
hemoglobin types part 1
hemoglobin types part 2 – hemoglobins of alpha thallasemia
hemoglobin types part 3
hemoglobin synthesis part 1
hemoglobin synthesis part 2 – Porphyrias
hemoglobin and RBC breakdown

Blood Groups

Blood Groups – Part 1 – The ABO system
Blood Groups – Part 2 – The Rh Blood Group System

Red blood cell indices

RBC indices

white blood cells – Neutrophils

Neutrophil Basics
Neutrophil extravasation
Neutrophil granules and phagocytosis
Neutrophil levels in the blood

white blood cells – Lymphocytes

Lymphocytes introduction
B amd T cells
Antibodies and humoral immunity
Affinity maturation
Class switching
Immunoglobulin M
Immunoglobulin G
Immunoglobulin A
Cell Mediated immunity – Part 1 – Natural killer cells
Cell Mediated immunity – Part 2 – Cytotoxic T cells

White blood cells – Eosinophils, Mast cells and Basophils.

Introduction to parasitic infections
Mast cells and Ig E

White blood cells – Monocytes, macrophages and dendritic cells.

Monocytes and macrophages
Dendritic cells


Platelet structure
Platelet production
Platelets and their function
The Coagulation Pathway
Anticoagulants in the blood



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